SPECIFIC CONTRIBUTION OF NEURAL AND HUMORAL MECHANISMS TO THE DEVELOPMENT OF ARTERIAL HYPERTENSION OF DIFFERENT ORIGIN: UNDER METABOLIC OBESITY AND ALCOHOL ADDICTION IN RATS

Abstract

Summary. Different medicines that affect distinct mechanisms of the arterial pressure diminishing are used in clinic for hypertension treatment - neural, humoral. It is unclear why these drugs display different effect in different patients. Impairment of neural and humoral chains of arterial pressure regulation under hypertony of different etiology is suggested to be unequal. Chronic hypertony of different genesis was developed in rats during 4 months: under alcoholism (n=10) and metabolic obesity (n=10). Emotional stress modeled by introducing caffeine. After that hypotensive medicines of different mechanism of action were administered: Concor cor (beta-adrenergic receptor blocker), Doxazosin (antagonist of alfa- adrenergic receptor), Prestarium (inhibitor of ACE). These drugs were applied separately of under the stress made by caffeine. Arterial pressure on the tail and the heart rate were registered using sphygmomanometer

Keywords

• hypertension
• alcohol
• caffeine
• sphygmomanometer