Nature Communications (Jun 2020)
Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
- Yohan Suryo Rahmanto,
- Wenjing Shen,
- Xu Shi,
- Xi Chen,
- Yu Yu,
- Zheng-Cheng Yu,
- Tsutomu Miyamoto,
- Meng-Horng Lee,
- Vivek Singh,
- Ryoichi Asaka,
- Geoffrey Shimberg,
- Michele I. Vitolo,
- Stuart S. Martin,
- Denis Wirtz,
- Ronny Drapkin,
- Jianhua Xuan,
- Tian-Li Wang,
- Ie-Ming Shih
Affiliations
- Yohan Suryo Rahmanto
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Wenjing Shen
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Xu Shi
- Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University
- Xi Chen
- Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University
- Yu Yu
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Zheng-Cheng Yu
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Tsutomu Miyamoto
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Meng-Horng Lee
- Department of Chemical and Biomolecular Engineering, Physical Sciences-Oncology Center, and Institute for NanoBioTechology, Johns Hopkins University
- Vivek Singh
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Ryoichi Asaka
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Geoffrey Shimberg
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Michele I. Vitolo
- Marlene and Stewart Greenebaum National Cancer Institute Cancer Center and Department of Physiology, University of Maryland
- Stuart S. Martin
- Marlene and Stewart Greenebaum National Cancer Institute Cancer Center and Department of Physiology, University of Maryland
- Denis Wirtz
- Department of Chemical and Biomolecular Engineering, Physical Sciences-Oncology Center, and Institute for NanoBioTechology, Johns Hopkins University
- Ronny Drapkin
- Department of Obstetrics and Gynecology, University of Pennsylvania
- Jianhua Xuan
- Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University
- Tian-Li Wang
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- Ie-Ming Shih
- Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions
- DOI
- https://doi.org/10.1038/s41467-020-16416-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
ARID1A, which is often mutated in human endometrial cancer, is a component of the SWI/SNF chromatin remodelling complex. Here, the authors show that Arid1a mutations in the mouse endometrium and primary human endometrial epithelial cells cause widespread reprogramming of gene transcription and result in a loss of response to TGFβ.
