Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research

Abstract

The following work presents a method for obtaining PLA composites with activated carbon modified using the liquid for fused deposition modeling (L-FDM) method in which two different compounds, i.e., rhodamine and antipyrine, are introduced. Tablets saturated with substances were obtained. Microscopic tests were carried out, and these confirmed the presence of substances that had been introduced into the polymer structure. UV-Vis spectra and observation of the active substance release process confirmed the relationship between the printing speed and the amounts of the compounds liberated from the tablets. Additionally, the contact angle of the PLA with activated carbon composites was characterized. The hydrophilic nature of the obtained composites favors an increase in the amounts of compounds released during the release process, which is a desirable effect. The surfaces and pores of the obtained materials were also analyzed. The incorporation of activated carbon into PLA results in a significant increase in its surface area. Investigations indicate that a novel approach for introducing chemicals into polymer matrices through the L-FDM method holds promise for the prospective fabrication of tablets capable of a controlled and customized release of substances tailored to individual requirements.

Keywords

• L-FDM
• liquid for fused deposition modeling
• printed medicines
• carbon composites