Nature Communications (Jun 2021)
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection
- Jing Geng,
- Yiran Shi,
- Jinjia Zhang,
- Bingying Yang,
- Ping Wang,
- Weihong Yuan,
- Hao Zhao,
- Junhong Li,
- Funiu Qin,
- Lixin Hong,
- Changchuan Xie,
- Xianming Deng,
- Yujie Sun,
- Congying Wu,
- Lanfen Chen,
- Dawang Zhou
Affiliations
- Jing Geng
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Yiran Shi
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Jinjia Zhang
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Bingying Yang
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Ping Wang
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Weihong Yuan
- National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong University
- Hao Zhao
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Junhong Li
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Funiu Qin
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Lixin Hong
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Changchuan Xie
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Xianming Deng
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Yujie Sun
- Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University
- Congying Wu
- Institute of Systems Biomedicine, Peking University Health Science Center
- Lanfen Chen
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- Dawang Zhou
- State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
- DOI
- https://doi.org/10.1038/s41467-021-23683-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Innate immune cells respond to a number of environmental cues including TLR signalling. Here the authors implicate mechanical sensor Piezo1 in the TLR4 mediated host response to bacterial infection and implicate it in the enhancement of macrophage mediated host response.
