Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Jan 2009)
ASSOCIATION OF ADMISSION INSULIN RESISTANCE INDEX WITH EARLY CARDIAC COMPLICATIONS IN NON DIABETIC PATIENTS WITH ACUTE CORONARY SYNDROME
Abstract
BACKGROUND AND OBJECTIVE: Insulin resistance is a risk for many cardiovascular diseases that the effect of it on prognosis and etiology is not clear. The aim of this study was to determine the association of admission insulin resistance index (AIRI) with prognosis in non diabetic patients with acute coronary syndrome (ACS).METHODS: This analytical study was done on 90 non diabetic patients with ACS in three groups including UA (unstable angina), STEMI (ST-elevation myocardial infarction) and NSTEMI (Non–ST-elevation myocardial infarction) in CCU ward of Shahid Beheshti hospital, Babol, Iran. The diagnosis of acute myocardial infarction was based on clinical criteria, elevation of cardiac enzyme and ECG (Electrocardiogram) changes. All of patients followed for complications and ejection fraction within 15 days after admission. 5 cc blood was obtained form all patients and insulin level and fasting blood sugar were measured after admission. Other data including history of diabetes, hypertension, smoking, family history, sex and age were recorded for all patients.FINDINGS: The mean age, sex distribution and distribution of cardiac risk factor (smoking, hypertension, hyperlipidemia, coronary artery disease, and family history) did not show significant difference between three groups. The mean of AIRI for NSTEMI, STEMI and UA was 6.9±6.6, 10.5±10.8 and 8.6±8.8, respectively. There was no significant difference between the mean AIRI in patients with complication (7.9±9.1) and without complication (8.7±8.8).CONCLUSION: The results of this study showed that AIRI does not seem suitable for detection of non diabetic ACS patients with left ventricular dysfunction.
