Nature Communications (Feb 2021)

Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

  • Parker J. Nichols,
  • Shaun Bevers,
  • Morkos Henen,
  • Jeffrey S. Kieft,
  • Quentin Vicens,
  • Beat Vögeli

DOI
https://doi.org/10.1038/s41467-021-21039-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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ADAR1 is an interferon-induced enzyme that catalyzes editing of adenine to inosine across the transcriptome as part of the immune response. Here the authors establish how ADAR1 recognizes non-CpG RNA sequences to facilitate the formation of A-Z junctions.