Substrate Binding Stiffens Aspartate Aminotransferase by Altering the Enzyme Picosecond Vibrational Dynamics

• Steven Dajnowicz,
• Yongqiang Cheng,
• Luke L. Daemen,
• Kevin L. Weiss,
• Oksana Gerlits,
• Timothy C. Mueser,
• Andrey Kovalevsky

Affiliations

Steven Dajnowicz

Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States

Yongqiang Cheng

Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States

Luke L. Daemen

Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States

Kevin L. Weiss

Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States

Oksana Gerlits

Department of Natural Sciences, Tennessee Wesleyan University, Athens, Tennessee, United States

Timothy C. Mueser

Department of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio, United States

Andrey Kovalevsky

Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States