精准医学杂志 (Jun 2023)

ANESTHETIC EFFECT OF PROPOFOL COMBINED WITH ESKETAMINE AND SUFENTANIL IN HYSTEROSCOPIC SURGERY

  • YAN Rubing, SUN Jingbo, HAN Shuai, SHI Jianwen, CHU Haichen, LIANG Yongxin

DOI
https://doi.org/10.13362/j.jpmed.202303011
Journal volume & issue
Vol. 38, no. 3
pp. 237 – 240

Abstract

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Objective To investigate the anesthetic effect of propofol combined with esketamine and sufentanil for intravenous anesthesia in hysteroscopic surgery. Methods A total of 90 patients who underwent elective hysteroscopic surgery were divided into sufentanil+propofol group (group A) and esketamine+sufentanil+propofol group (group B). Mean arterial pressure (MAP), heart rate (HR), and pulse oxygen saturation (SpO2) were recorded before anesthesia (T0), when eyelash reflex disappeared (T1), at cervix dilation (T2), at the end of surgery (T3), and at the time of awaking from anesthesia (T4), and the amount of propofol used, time of operation, awakening time after surgery, Visual Analog Scale (VAS) score of postoperative pain, and Ramsay sedation score were recorded, as well as the incidence rate of perioperative adverse events. Results Compared with group A, group B had a significant increase in MAP at T1, T2, T3, and T4 (F=19.121-32.681,P<0.05) and significant increases in SpO2 and HR at T1 and T2 (F=6.868-18.551,P<0.05); in addition, group B had a significant reduction in the amount of propofol used during surgery, a significantly shorter postoperative awakening time, and a significant reduction in postoperative Ramsay sedation score (W=1 453.000,t=6.059,3.321,P<0.05), as well as significant reductions in the composition ratio of respiratory depression, body movement, hypotension, sinus bradycardia, and the degree of respiratory depression (χ2=4.464-11.072,W=1 669.500,P<0.05). There were no significant differences between the two groups in time of operation, postoperative VAS score, psychotomimetic symptoms, and adverse reactions including nausea and vomiting (P>0.05). Conclusion Propofol combined with esketamine and sufentanil for intravenous anesthesia in hysteroscopic surgery has a relatively satisfactory anesthetic effect and can effectively stabilize intraoperative blood pressure, HR, and blood oxygen saturation, with a significant reduction in the amount of propofol used during surgery, a significantly shortened awakening time, and few adverse reactions, and therefore, it holds promise for clinical application.

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