Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3

Romain O. Georges; Hugo Sepulveda; J. Carlos Angel; Eric Johnson; Susan Palomino; Roberta B. Nowak; Arshad Desai; Isaac F. López-Moyado; Anjana Rao

doi:10.1038/s41467-022-33742-7

Nature Communications (Oct 2022)

Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3

Romain O. Georges,
Hugo Sepulveda,
J. Carlos Angel,
Eric Johnson,
Susan Palomino,
Roberta B. Nowak,
Arshad Desai,
Isaac F. López-Moyado,
Anjana Rao

Affiliations

Romain O. Georges: Division of Signaling and Gene Expression, La Jolla Institute for Immunology
Hugo Sepulveda: Division of Signaling and Gene Expression, La Jolla Institute for Immunology
J. Carlos Angel: Division of Signaling and Gene Expression, La Jolla Institute for Immunology
Eric Johnson: Division of Signaling and Gene Expression, La Jolla Institute for Immunology
Susan Palomino: Division of Signaling and Gene Expression, La Jolla Institute for Immunology
Roberta B. Nowak: Division of Signaling and Gene Expression, La Jolla Institute for Immunology
Arshad Desai: Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego
Isaac F. López-Moyado: Division of Signaling and Gene Expression, La Jolla Institute for Immunology
Anjana Rao: Division of Signaling and Gene Expression, La Jolla Institute for Immunology

DOI: https://doi.org/10.1038/s41467-022-33742-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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