NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

Yasuhiro Yamamoto; Haruka Chino; Satoshi Tsukamoto; Koji L. Ode; Hiroki R. Ueda; Noboru Mizushima

doi:10.1038/s41467-021-23599-7

Nature Communications (Jun 2021)

NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

Yasuhiro Yamamoto,
Haruka Chino,
Satoshi Tsukamoto,
Koji L. Ode,
Hiroki R. Ueda,
Noboru Mizushima

Affiliations

Yasuhiro Yamamoto: Department of Biochemistry and Molecular Biology, The University of Tokyo
Haruka Chino: Department of Biochemistry and Molecular Biology, The University of Tokyo
Satoshi Tsukamoto: Laboratory Animal and Genome Sciences Section, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
Koji L. Ode: Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo
Hiroki R. Ueda: Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo
Noboru Mizushima: Department of Biochemistry and Molecular Biology, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-021-23599-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic degradation via GABARAP interaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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