PLoS ONE (Jan 2021)

Survival outcome and prognostic factors of patients with nasopharyngeal cancer in Yogyakarta, Indonesia: A hospital-based retrospective study.

  • Susanna Hilda Hutajulu,
  • Daniel Howdon,
  • Kartika Widayati Taroeno-Hariadi,
  • Mardiah Suci Hardianti,
  • Ibnu Purwanto,
  • Sagung Rai Indrasari,
  • Camelia Herdini,
  • Bambang Hariwiyanto,
  • Ahmad Ghozali,
  • Henry Kusumo,
  • Wigati Dhamiyati,
  • Sri Retna Dwidanarti,
  • I Bing Tan,
  • Johan Kurnianda,
  • Matthew John Allsop

DOI
https://doi.org/10.1371/journal.pone.0246638
Journal volume & issue
Vol. 16, no. 2
p. e0246638

Abstract

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PurposeThis study aimed to determine the survival outcome and prognostic factors of patients with nasopharyngeal cancer accessing treatment in Yogyakarta, Indonesia.MethodsData on 759 patients with NPC diagnosed from 2007 to 2016 at Dr Sardjito General Hospital were included. Potential prognostic variables included sociodemographic, clinicopathology and treatment parameters. Multivariable analyses were implemented using semi-parametric Cox proportional hazards modelling and fully parametric survival analysis.ResultsThe median time of observation was 14.39 months. In the whole cohort the median observed survival was 31.08 months. In the univariable analysis, age, education status, insurance type, BMI, ECOG index, stage and treatment strategy had an impact on overall survival (OS) (p values ConclusionsMedian OS for the cohort was low compared to those reported in both endemic and non-endemic regions. By combining the findings of multivariable analyses, we showed that age, education status, ECOG index, stage and first treatment modality were independent predictors for the OS.