Nature Communications (Aug 2016)
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
- Solveig K. Sieberts,
- Fan Zhu,
- Javier García-García,
- Eli Stahl,
- Abhishek Pratap,
- Gaurav Pandey,
- Dimitrios Pappas,
- Daniel Aguilar,
- Bernat Anton,
- Jaume Bonet,
- Ridvan Eksi,
- Oriol Fornés,
- Emre Guney,
- Hongdong Li,
- Manuel Alejandro Marín,
- Bharat Panwar,
- Joan Planas-Iglesias,
- Daniel Poglayen,
- Jing Cui,
- Andre O. Falcao,
- Christine Suver,
- Bruce Hoff,
- Venkat S. K. Balagurusamy,
- Donna Dillenberger,
- Elias Chaibub Neto,
- Thea Norman,
- Tero Aittokallio,
- Muhammad Ammad-ud-din,
- Chloe-Agathe Azencott,
- Víctor Bellón,
- Valentina Boeva,
- Kerstin Bunte,
- Himanshu Chheda,
- Lu Cheng,
- Jukka Corander,
- Michel Dumontier,
- Anna Goldenberg,
- Peddinti Gopalacharyulu,
- Mohsen Hajiloo,
- Daniel Hidru,
- Alok Jaiswal,
- Samuel Kaski,
- Beyrem Khalfaoui,
- Suleiman Ali Khan,
- Eric R. Kramer,
- Pekka Marttinen,
- Aziz M. Mezlini,
- Bhuvan Molparia,
- Matti Pirinen,
- Janna Saarela,
- Matthias Samwald,
- Véronique Stoven,
- Hao Tang,
- Jing Tang,
- Ali Torkamani,
- Jean-Phillipe Vert,
- Bo Wang,
- Tao Wang,
- Krister Wennerberg,
- Nathan E. Wineinger,
- Guanghua Xiao,
- Yang Xie,
- Rae Yeung,
- Xiaowei Zhan,
- Cheng Zhao,
- Members of the Rheumatoid Arthritis Challenge Consortium,
- Jeff Greenberg,
- Joel Kremer,
- Kaleb Michaud,
- Anne Barton,
- Marieke Coenen,
- Xavier Mariette,
- Corinne Miceli,
- Nancy Shadick,
- Michael Weinblatt,
- Niek de Vries,
- Paul P. Tak,
- Danielle Gerlag,
- Tom W. J. Huizinga,
- Fina Kurreeman,
- Cornelia F. Allaart,
- S. Louis Bridges Jr.,
- Lindsey Criswell,
- Larry Moreland,
- Lars Klareskog,
- Saedis Saevarsdottir,
- Leonid Padyukov,
- Peter K. Gregersen,
- Stephen Friend,
- Robert Plenge,
- Gustavo Stolovitzky,
- Baldo Oliva,
- Yuanfang Guan,
- Lara M. Mangravite
Affiliations
- Solveig K. Sieberts
- Sage Bionetworks
- Fan Zhu
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Javier García-García
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Eli Stahl
- Division of Psychiatric Genomics, Center for Statistical Genetics, Icahn School of Medicine at Mount Sinai
- Abhishek Pratap
- Sage Bionetworks
- Gaurav Pandey
- Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Dimitrios Pappas
- Division of Rheumatology, Department of Medicine, Columbia University
- Daniel Aguilar
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Bernat Anton
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Jaume Bonet
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Ridvan Eksi
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Oriol Fornés
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Emre Guney
- Center for Complex Network Research, Northeastern University
- Hongdong Li
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Manuel Alejandro Marín
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Bharat Panwar
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Joan Planas-Iglesias
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Daniel Poglayen
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Jing Cui
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Andre O. Falcao
- Department of Informatics, Faculty of Sciences, University of Lisbon
- Christine Suver
- Sage Bionetworks
- Bruce Hoff
- Sage Bionetworks
- Venkat S. K. Balagurusamy
- IBM T.J. Watson Research Center, Yorktown Heights
- Donna Dillenberger
- IBM T.J. Watson Research Center, Yorktown Heights
- Elias Chaibub Neto
- Sage Bionetworks
- Thea Norman
- Sage Bionetworks
- Tero Aittokallio
- IBM T.J. Watson Research Center, Yorktown Heights
- Muhammad Ammad-ud-din
- Department of Computer Science, Aalto University
- Chloe-Agathe Azencott
- MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology
- Víctor Bellón
- MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology
- Valentina Boeva
- MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology
- Kerstin Bunte
- Department of Computer Science, Aalto University
- Himanshu Chheda
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Lu Cheng
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Jukka Corander
- Helsinki Institute for Information Technology (HIIT)
- Michel Dumontier
- Stanford Center for Biomedical Informatics, Stanford University
- Anna Goldenberg
- Department of Computer Science, University of Toronto
- Peddinti Gopalacharyulu
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Mohsen Hajiloo
- Genetics and Genome Biology, SickKids Research Institute
- Daniel Hidru
- Department of Computer Science, University of Toronto
- Alok Jaiswal
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Samuel Kaski
- Department of Computer Science, Aalto University
- Beyrem Khalfaoui
- Genetics and Genome Biology, SickKids Research Institute
- Suleiman Ali Khan
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Eric R. Kramer
- Department of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute
- Pekka Marttinen
- Department of Computer Science, Aalto University
- Aziz M. Mezlini
- Department of Computer Science, University of Toronto
- Bhuvan Molparia
- Department of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute
- Matti Pirinen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Janna Saarela
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Matthias Samwald
- Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna
- Véronique Stoven
- MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology
- Hao Tang
- Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center
- Jing Tang
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Ali Torkamani
- Department of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute
- Jean-Phillipe Vert
- MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology
- Bo Wang
- Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center
- Tao Wang
- Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center
- Krister Wennerberg
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Nathan E. Wineinger
- Department of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute
- Guanghua Xiao
- Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center
- Yang Xie
- Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center
- Rae Yeung
- Department of Paediatrics, Department of Immunology, Institute of Medical Sciences, University of Toronto
- Xiaowei Zhan
- Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center
- Cheng Zhao
- Department of Computer Science, University of Toronto
- Members of the Rheumatoid Arthritis Challenge Consortium
- Jeff Greenberg
- Sage Bionetworks
- Joel Kremer
- Department of Medicine, Division of Rheumatology, Albany Medical College
- Kaleb Michaud
- Department of Medicine, University of Nebraska Medical Center
- Anne Barton
- Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester
- Marieke Coenen
- Department of Human Genetics, Radboud University Nijmegen Medical Centre
- Xavier Mariette
- Department of Rheumatology, Université Paris-Sud
- Corinne Miceli
- Department of Rheumatology, Université Paris-Sud
- Nancy Shadick
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Michael Weinblatt
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard Medical School
- Niek de Vries
- Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam
- Paul P. Tak
- Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam
- Danielle Gerlag
- Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam
- Tom W. J. Huizinga
- Department of Rheumatology, Leiden University Medical Centre
- Fina Kurreeman
- Department of Rheumatology, Leiden University Medical Centre
- Cornelia F. Allaart
- Merck Research Labs, Merck and Co., Inc., Boston
- S. Louis Bridges Jr.
- Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham
- Lindsey Criswell
- Division of Rheumatology, Department of Medicine, Rosalind Russell/Ephraim P Engleman Rheumatology Research Center, University of California San Francisco
- Larry Moreland
- Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh
- Lars Klareskog
- Department of Medicine, Rheumatology Unit, Karolinska Hospital and Karolinska Institutet
- Saedis Saevarsdottir
- Department of Medicine, Rheumatology Unit, Karolinska Hospital and Karolinska Institutet
- Leonid Padyukov
- Department of Medicine, Rheumatology Unit, Karolinska Hospital and Karolinska Institutet
- Peter K. Gregersen
- Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System
- Stephen Friend
- Sage Bionetworks
- Robert Plenge
- Merck Research Labs, Merck and Co., Inc., Boston
- Gustavo Stolovitzky
- Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Baldo Oliva
- Structural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Yuanfang Guan
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Lara M. Mangravite
- Sage Bionetworks
- DOI
- https://doi.org/10.1038/ncomms12460
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Rheumatoid arthritis patients respond differently to anti-TNF treatment. Using community-based challenge, the authors show that currently available data does not reveal meaningful genetic predictors of response to anti-TNF therapy, thus confirming clinical observations.
