Communications Biology (Mar 2021)

Expanding the drug discovery space with predicted metabolite–target interactions

  • Andrea Nuzzo,
  • Somdutta Saha,
  • Ellen Berg,
  • Channa Jayawickreme,
  • Joel Tocker,
  • James R. Brown

DOI
https://doi.org/10.1038/s42003-021-01822-x
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Using computational approaches, Nuzzo et al. identify 983 potential metabolite–human target interactions from the Inflammatory Bowel Disease (IBD) cohort dataset of the Human Microbiome Project 2 (HMP2) and public databases. These predicted interactions can further the understanding of host–microbiome interactions and assist in drug discovery for IBD and other diseases.