Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity

Abstract

Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The purpose of this study was to evaluate LDHRS and the effect of PLDR irradiation in isogenic HNSCC cells with different radiosensitivity.

Keywords

• dna damage
• isogenic cell lines
• low dose irradiation
• pulsed low dose-rate irradiation
• radiosensitivity