Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population
Peng Huang,
Jing-Jing Wu,
Jin-Wei Zhang,
Yu-Qing Hou,
Ping Zhu,
Rong Yin,
Rong-Bin Yu,
Yun Zhang,
Ming Yue,
Wei Hou
Affiliations
Peng Huang
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Jing-Jing Wu
The Department of Environmental Health, Yangzhou Center for Disease Control and Prevention, Yang-zhou, China
Jin-Wei Zhang
Department of Anesthesiology, Nanjing Drum Tower Hospital, Nanjing, China
Yu-Qing Hou
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Ping Zhu
Department of Medical Affairs, Jiangsu Provincial People’s Hospital, Nanjing, China
Rong Yin
Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital & Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China
Rong-Bin Yu
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Yun Zhang
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Ming Yue
Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Wei Hou
The State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China
Hepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs2074160) to assess their association with the chronicity of hepatitis C virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases and 1,000 persistent infection patients). Our research shows that DHX58 rs2074158-G allele (dominant model: adjusted OR = 1.53, 95% CI [1.20–1.95], P = 0.001; additive model: adjusted OR = 1.50, 95% CI [1.27–1.78], P < 0.001) and IFIH1 rs10930046-C allele (additive model: adjusted OR = 1.26, 95% CI [1.07–1.49], P = 0.005) were associated with chronic hepatitis C (CHC). And the risk of CHC increased in people carrying more unfavorable genotypes (rs2074158-AG/GG or rs10930046-CC), with the chronic rates for genotypes number from zero to two in 60.69%, 57.33%, and 85.93%, respectively (adjusted OR = 3.64, 95% CI [2.18–6.08]; P < 0.001). Genetic polymorphism of IFIH1 and DHX58 may be related to CHC in the Chinese Han population. Furthermore, the risk of CHC increases as the number of unfavorable genotypes carried by the HCV-infected person increases. IFIH1 rs10930046, DHX58 rs2074158, age, ALT, and AST levels were all independent predictors of CHC.
