Biochemical Markers of Lipid Metabolism Disorders in Children with Hepatic Steatosis

Abstract

Peculiarities of blood lipids were studied in children with functional disorders of the biliary tract (FDBT) and liver steatosis. We have examined 28 children aged 10 to 17 years, who sought medical help in the department of pediatric gastroenterology of State institution «Institute of gastroenterology of National academy of medical sciences of Ukraine». The presence of steatosis was determined by means of liver transient elastography with the study of controlled parameter of ultrasonic attenuation. According to the findings, we have formed two groups: I group — 17 children with FDBT without steatosis; II group — 11 children with FDBT and steatosis. As research markers of serum lipids, we have used the content of total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and atherogenic factor was calculated. It was found that children with FDBT are characterized by dyslipidemia, which manifests itself in the reduction of very low-density lipoprotein cholesterol, increase of low-density lipoprotein cholesterol and atherogenic factor. Signs of metabolic syndrome are characteristic of the blood lipids of children with steatosis.

Keywords

• lipid metabolism
• hepatic steatosis
• children