Salivary Metabolic Profiling of Systemic Disorders and Oral Neoplastic and Preneoplastic Conditions- A Narrative Review

Abstract

Salivary metabolic profiling has emerged as an important mode of analysing the metabolic markers that aids in early disease detection in various systemic diseases. The metabolomics study states that, the transitional and the end products of interactions that take place between genes, proteins, and the environment are found to be involved in various disease processes. Salivary metabolomics stands as a highly specific and sensitive method in diagnosis of various conditions making it a better alternative to the conventional serum and tissue-based methods well. These metabolomics studies incorporate various analytical technologies for identifying each component that could be used as a biomarker. Hence, we reviewed the current state of salivary metabolomics, diagnostic efficiency and its associated technologies and its future role in identification and monitoring the disease prognosis. The study selection was done by locating those research papers that provided information on salivary diagnostics using metabolic markers for early diagnosis in systemic disorders, neoplastic and preneoplastic conditions with help of search engines like Pubmed, Google Scholar, Web of Science and Cochrane library. The results of each study were critically evaluated to accentuate the principal role played by these biomarkers in the field of salivary diagnostics.

Keywords

• biomarkers
• genomics
• proteomics
• salivary metabolomics
• transcriptomes