Nature Communications (Apr 2023)
Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism
- Pascale Baden,
- Maria Jose Perez,
- Hariam Raji,
- Federico Bertoli,
- Stefanie Kalb,
- María Illescas,
- Fokion Spanos,
- Claudio Giuliano,
- Alessandra Maria Calogero,
- Marvin Oldrati,
- Hannah Hebestreit,
- Graziella Cappelletti,
- Kathrin Brockmann,
- Thomas Gasser,
- Anthony H. V. Schapira,
- Cristina Ugalde,
- Michela Deleidi
Affiliations
- Pascale Baden
- German Center for Neurodegenerative Diseases (DZNE)
- Maria Jose Perez
- German Center for Neurodegenerative Diseases (DZNE)
- Hariam Raji
- German Center for Neurodegenerative Diseases (DZNE)
- Federico Bertoli
- German Center for Neurodegenerative Diseases (DZNE)
- Stefanie Kalb
- German Center for Neurodegenerative Diseases (DZNE)
- María Illescas
- Instituto de Investigación Hospital 12 de Octubre (i + 12)
- Fokion Spanos
- German Center for Neurodegenerative Diseases (DZNE)
- Claudio Giuliano
- German Center for Neurodegenerative Diseases (DZNE)
- Alessandra Maria Calogero
- Department of Biosciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano
- Marvin Oldrati
- German Center for Neurodegenerative Diseases (DZNE)
- Hannah Hebestreit
- German Center for Neurodegenerative Diseases (DZNE)
- Graziella Cappelletti
- Department of Biosciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano
- Kathrin Brockmann
- German Center for Neurodegenerative Diseases (DZNE)
- Thomas Gasser
- German Center for Neurodegenerative Diseases (DZNE)
- Anthony H. V. Schapira
- Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network
- Cristina Ugalde
- Instituto de Investigación Hospital 12 de Octubre (i + 12)
- Michela Deleidi
- German Center for Neurodegenerative Diseases (DZNE)
- DOI
- https://doi.org/10.1038/s41467-023-37454-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
GBA1 mutations cause Gaucher’s disease and are the strongest risk factor for Parkinson’s disease. Using stable cell lines and patient iPSCs, the authors show mitochondrial localization of GBA1, which may affect neurodegenerative disease risk.
