Drug - drug interaction in a patient with epilepsy and newly diagnosed paroxysmal atrial fibroundulation

Abstract

Cytochrome P450 isoenzymes have a major role in the metabolism of xenobiotics. They are mostly found in hepatocytes and oxidize majority of drugs, thus shifting them into their inactive form. Some of them can influence cytochromes’ activity while getting oxidized, simultaneously inducing or inhibiting them. This way, drug activity can be altered and their benefit in the management of the disease limited.

Keywords

• anticoagulants
• carbamazepine
• cytochromes
• phenobarbital