Association between serum uric acid/HDL-cholesterol ratio and chronic kidney disease: a cross-sectional study based on a health check-up population

Abstract

Objective Evidence suggests that both serum uric acid (SUA) and high-density lipoprotein cholesterol (HDL-C) are risk factors for chronic kidney disease (CKD). The SUA-to-HDL-C ratio (UHR) has recently attracted attention as a new biomarker to evaluate the role between inflammatory and anti-inflammatory substances. Thus, we explored the association between UHR and CKD in a large Chinese population.Design A cross-sectional study.Setting Annual health check-up population in Nanjing.Participants 19 458 individuals who underwent an annual health check-up in 2019 were included in our study.Main outcome measure CKD was diagnosed according to an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2.Results Correlation analysis showed that UHR was negatively associated with eGFR after adjusting for confounding factors (r=−0.34). In addition, participants in the highest quartile of UHR had a higher risk of CKD than those in the lowest quartiles (OR=9.28, p<0.001).Conclusion We found that high UHR values were positively associated with CKD risk in health check-up population. An increased UHR may be a useful measure by which to assess CKD risk in the preclinical stage.