Features of the Content of Cellular Messengers of Inflammation in Eye Injuries

Abstract

Eye injury is one of the actual problems in modern ophthalmology. Penetrating wounds of the cornea are the most significant among all eye injuries. New data on the course of inflammation in corneal injury will allow us to predict the course of the post-traumatic period and improve treatment outcomes. The corneal immune privilege is a unique system of protecting one’s own tissues from damage caused by systemic immunity reactions, which is realized through several mechanisms. Modern research shows that healing from corneal injury is a complex cascade of cellular reactions, the understanding of which is still far from consummation. It was described the regenerative potential of cell populations of the cornea when it was damaged. Contravention of barrier properties in injuries of the cornea deprives the organ of vision of immune privilege. This violation initiates the launch of the messenger pools of angiogenesis, remodeling and inflammation. Besides studying the interaction of cellular messengers in cornea trauma and inflammation, researchers pay great attention to cellular reactions. Recruitment of immune cells during corneal injury is mediated by pro-inflammatory cytokines released during damage from epithelial cells and keratocytes.

Keywords

• cornea
• corneal injury
• corneal regeneration
• inflammation in corneal injury