Nature Communications (Jun 2018)
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints
- Ayenachew Bezawork-Geleta,
- He Wen,
- LanFeng Dong,
- Bing Yan,
- Jelena Vider,
- Stepana Boukalova,
- Linda Krobova,
- Katerina Vanova,
- Renata Zobalova,
- Margarita Sobol,
- Pavel Hozak,
- Silvia Magalhaes Novais,
- Veronika Caisova,
- Pavel Abaffy,
- Ravindra Naraine,
- Ying Pang,
- Thiri Zaw,
- Ping Zhang,
- Radek Sindelka,
- Mikael Kubista,
- Steven Zuryn,
- Mark P. Molloy,
- Michael V. Berridge,
- Karel Pacak,
- Jakub Rohlena,
- Sunghyouk Park,
- Jiri Neuzil
Affiliations
- Ayenachew Bezawork-Geleta
- School of Medical Sciences, Griffith University
- He Wen
- Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine
- LanFeng Dong
- School of Medical Sciences, Griffith University
- Bing Yan
- School of Medical Sciences, Griffith University
- Jelena Vider
- School of Medical Sciences, Griffith University
- Stepana Boukalova
- Institute of Biotechnology, Czech Academy of Sciences
- Linda Krobova
- Institute of Biotechnology, Czech Academy of Sciences
- Katerina Vanova
- Institute of Biotechnology, Czech Academy of Sciences
- Renata Zobalova
- Institute of Biotechnology, Czech Academy of Sciences
- Margarita Sobol
- Institute of Molecular Genetics, Czech Academy of Sciences
- Pavel Hozak
- Institute of Molecular Genetics, Czech Academy of Sciences
- Silvia Magalhaes Novais
- Institute of Biotechnology, Czech Academy of Sciences
- Veronika Caisova
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
- Pavel Abaffy
- Institute of Biotechnology, Czech Academy of Sciences
- Ravindra Naraine
- Institute of Biotechnology, Czech Academy of Sciences
- Ying Pang
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
- Thiri Zaw
- Australian Proteome Analysis Facility, Macquarie University
- Ping Zhang
- School of Medical Sciences, Griffith University
- Radek Sindelka
- Institute of Biotechnology, Czech Academy of Sciences
- Mikael Kubista
- Institute of Biotechnology, Czech Academy of Sciences
- Steven Zuryn
- Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, University of Queensland
- Mark P. Molloy
- Australian Proteome Analysis Facility, Macquarie University
- Michael V. Berridge
- Malaghan Institute of Medical Research
- Karel Pacak
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
- Jakub Rohlena
- Institute of Biotechnology, Czech Academy of Sciences
- Sunghyouk Park
- College of Pharmacy, Natural Product Research Institute, Seoul National University
- Jiri Neuzil
- School of Medical Sciences, Griffith University
- DOI
- https://doi.org/10.1038/s41467-018-04603-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Mitochondrial complex II is normally composed of four subunits. Here the authors show that bioenergetic stress conditions give rise to a partially assembled variant of complex II, which shifts the anabolic pathways to less energy demanding processes.
