The lipid-lowering therapy effectiveness and IHD course after coronary stenting

Abstract

Objective: to examine the relationship between the achievement of goal lipid metabolism and incidence of adverse cardiovascular events in patients after successful coronary stenting. Materials and Methods: The database for the study was data from 198 histories of patients with various forms of ischemic heart disease, who underwent coronary angiography, 306 stents implanted in coronary arteries in a regional cardiology center and Mechnikov regional hospital, Dnepropetrovsk over the period from 2004 to 2008. The period of observation of patients was on average 4,6 ± 1,3 years. Results and Discussion: The study found that the best five-year survival rate of patients without adverse cardiovascular events after stenting was significantly associated with previous PCI, presence of stable angina not higher than 2nd FC (61%, p<0,0001), achieving target level of CH-LDL (35%, p = 0.014), TG level less than 1,7 mmol/l was associated with a sta¬tistically significant reduction in risk of the primary endpoint 0,68 (long-rank p <0,0001) while taking statins after stenting. Conclusions: Achieving level of total cholesterol less than 4.5 mmol / L was not significantly associated with a decrease in the frequency of adverse CAP after successful stenting, but the level of 5-year survival was significantly associated with the achievement of target levels of LDL cholesterol, less than 2.5 mg/dL and triglycerides less than 1.7 mmol/l.

Keywords

• chronic ischemic heart disease
• coronary stenting
• lipid profile
• statins