Nature Communications (Feb 2016)

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

  • Emmanuele Crespan,
  • Antonia Furrer,
  • Marcel Rösinger,
  • Federica Bertoletti,
  • Elisa Mentegari,
  • Giulia Chiapparini,
  • Ralph Imhof,
  • Nathalie Ziegler,
  • Shana J. Sturla,
  • Ulrich Hübscher,
  • Barbara van Loon,
  • Giovanni Maga

DOI
https://doi.org/10.1038/ncomms10805
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides during synthesis.