Nature Communications (Aug 2019)

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

  • Sarah V. Faull,
  • Andy M. C. Lau,
  • Chloe Martens,
  • Zainab Ahdash,
  • Kjetil Hansen,
  • Hugo Yebenes,
  • Carla Schmidt,
  • Fabienne Beuron,
  • Nora B. Cronin,
  • Edward P. Morris,
  • Argyris Politis

DOI
https://doi.org/10.1038/s41467-019-11772-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The COP9 signalosome (CSN) regulates Cullin-RING Ligase 2 (CRL2) but the molecular basis for their interaction is unknown. Here the authors use structural mass spectrometry and cryo-EM approaches to assess the structures and dynamics of CSN-CRL2 complexes.