Green Synthetized Selenium Nanoparticles Using <i>Syzygium aromaticum</i> (Clove) Extract Reduce Pentylenetetrazol-Induced Epilepsy and Associated Cortical Damage in Rats

Mohamed S. Othman; Sofian T. Obeidat; Ghada M. Aleid; Amal H. Al-Bagawi; Mohamed A. Fareid; Reda Abdel Hameed; Kareem M. Mohamed; Mohamed S. Abdelfattah; Alaa Fehaid; Manal M. Hussein; Shimaa M. H. Aboelnaga; Ahmed E. Abdel Moneim

doi:10.3390/app13021050

Applied Sciences (Jan 2023)

Green Synthetized Selenium Nanoparticles Using <i>Syzygium aromaticum</i> (Clove) Extract Reduce Pentylenetetrazol-Induced Epilepsy and Associated Cortical Damage in Rats

Mohamed S. Othman,
Sofian T. Obeidat,
Ghada M. Aleid,
Amal H. Al-Bagawi,
Mohamed A. Fareid,
Reda Abdel Hameed,
Kareem M. Mohamed,
Mohamed S. Abdelfattah,
Alaa Fehaid,
Manal M. Hussein,
Shimaa M. H. Aboelnaga,
Ahmed E. Abdel Moneim

Affiliations

Mohamed S. Othman: Basic Sciences Department, Deanship of Preparatory Year, University of Ha’il, Hail 2440, Saudi Arabia
Sofian T. Obeidat: Basic Sciences Department, Deanship of Preparatory Year, University of Ha’il, Hail 2440, Saudi Arabia
Ghada M. Aleid: Basic Sciences Department, Deanship of Preparatory Year, University of Ha’il, Hail 2440, Saudi Arabia
Amal H. Al-Bagawi: Chemistry Department, Faculty of Science, University of Ha’il, Hail 2440, Saudi Arabia
Mohamed A. Fareid: Basic Sciences Department, Deanship of Preparatory Year, University of Ha’il, Hail 2440, Saudi Arabia
Reda Abdel Hameed: Basic Sciences Department, Deanship of Preparatory Year, University of Ha’il, Hail 2440, Saudi Arabia
Kareem M. Mohamed: Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Mohamed S. Abdelfattah: Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Alaa Fehaid: Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Mansoura University, Dakahlia 35516, Egypt
Manal M. Hussein: Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
Shimaa M. H. Aboelnaga: Basic Sciences Department, Deanship of Preparatory Year, University of Ha’il, Hail 2440, Saudi Arabia
Ahmed E. Abdel Moneim: Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo 11795, Egypt

DOI: https://doi.org/10.3390/app13021050
Journal volume & issue: Vol. 13, no. 2
p. 1050

Abstract

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We aimed to investigate the potential anticonvulsant effect of green synthetized selenium nanoparticles (SeNPs) using Syzygium aromaticum extract (SAE) (SAE-SeNPs) against epileptic seizures and cortical damage induced by pentylenetetrazole (PTZ) injection in rats and its mechanism. A total of 84 rats were divided into six groups; control, PTZ-exposed group, SAE + PTZ-treated group, sodium selenite (Na2SeO3) + PTZ-treated group, SAE-SeNPs + PTZ-treated group, and diazepam + PTZ-treated group. SAE-SeNPs significantly increase (p p p p < 0.05) the PTZ-induced changes in the neurotransmitter norepinephrine level and acetylcholinesterase enzymatic activity. These data concluded the anticonvulsant activity of SAE-SeNPs via their antioxidant, anti-inflammatory, and anti-apoptotic effects, along with their ability to modulate neurotransmitters.

Published in Applied Sciences

ISSN: 2076-3417 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General); Science: Biology (General); Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/applsci

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