Analysis of Amniocentesis Results in a Tertiary Care Center: A Retrospective Cohort Study

Abstract

Objective: To investigate the results of patients who underwent amniocentesis. Methods: Information about patients who underwent amniocentesis between May 2021 and May 2022 at the perinatology department of training and research hospital was obtained from the database and evaluated. The demographic characteristics of the patients, indications for amniocentesis, and clinical results of the procedures were also evaluated. Maternal age, gestational age at the time of amniocentesis, amniocentesis indication, and karyotyping results were reviewed and analyzed. Results: A total of 579 patients were included in the study. The mean ages of the patients and weeks of gestation at the time of the procedure were 32.28 (minimum 17, maximum 50) and 16.32 (minimum 14, maximum 32), respectively. Amniocentesis was most frequently performed in our clinic, with an indication for increased risk according to the dual screening test. Clear chromosome analysis could not be performed using the quantitative fluorescent polymerase chain reaction method in 17 patients, and 38 patients had an abnormal result for long-term cell culture. Conclusion: Amniocentesis is a frequently used fetal invasive karyotyping procedure. Amniocentesis indications are increasing with the progress of prenatal diagnosis. It is a relatively safe procedure when performed by experienced hands.

Keywords

• amniocentesis
• fetal invasive karyotyping
• increased risk in screening test
• qf-pcr