Nature Communications (Oct 2021)
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
- Fabien Thery,
- Lia Martina,
- Caroline Asselman,
- Yifeng Zhang,
- Madeleine Vessely,
- Heidi Repo,
- Koen Sedeyn,
- George D. Moschonas,
- Clara Bredow,
- Qi Wen Teo,
- Jingshu Zhang,
- Kevin Leandro,
- Denzel Eggermont,
- Delphine De Sutter,
- Katie Boucher,
- Tino Hochepied,
- Nele Festjens,
- Nico Callewaert,
- Xavier Saelens,
- Bart Dermaut,
- Klaus-Peter Knobeloch,
- Antje Beling,
- Sumana Sanyal,
- Lilliana Radoshevich,
- Sven Eyckerman,
- Francis Impens
Affiliations
- Fabien Thery
- VIB-UGent Center for Medical Biotechnology, VIB
- Lia Martina
- VIB-UGent Center for Medical Biotechnology, VIB
- Caroline Asselman
- VIB-UGent Center for Medical Biotechnology, VIB
- Yifeng Zhang
- Department of Microbiology and Immunology, University of Iowa Carver College of Medicine
- Madeleine Vessely
- Department of Microbiology and Immunology, University of Iowa Carver College of Medicine
- Heidi Repo
- VIB-UGent Center for Medical Biotechnology, VIB
- Koen Sedeyn
- VIB-UGent Center for Medical Biotechnology, VIB
- George D. Moschonas
- VIB-UGent Center for Medical Biotechnology, VIB
- Clara Bredow
- Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Biochemistry
- Qi Wen Teo
- HKU-Pasteur Research Pole, School of Public Health, University of Hong Kong
- Jingshu Zhang
- HKU-Pasteur Research Pole, School of Public Health, University of Hong Kong
- Kevin Leandro
- VIB-UGent Center for Medical Biotechnology, VIB
- Denzel Eggermont
- VIB-UGent Center for Medical Biotechnology, VIB
- Delphine De Sutter
- VIB-UGent Center for Medical Biotechnology, VIB
- Katie Boucher
- VIB-UGent Center for Medical Biotechnology, VIB
- Tino Hochepied
- VIB Center for Inflammation Research, VIB
- Nele Festjens
- VIB-UGent Center for Medical Biotechnology, VIB
- Nico Callewaert
- VIB-UGent Center for Medical Biotechnology, VIB
- Xavier Saelens
- VIB-UGent Center for Medical Biotechnology, VIB
- Bart Dermaut
- Department of Biomolecular Medicine, Ghent University
- Klaus-Peter Knobeloch
- Institute of Neuropathology, Medical Faculty, University of Freiburg
- Antje Beling
- Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Biochemistry
- Sumana Sanyal
- HKU-Pasteur Research Pole, School of Public Health, University of Hong Kong
- Lilliana Radoshevich
- Department of Microbiology and Immunology, University of Iowa Carver College of Medicine
- Sven Eyckerman
- VIB-UGent Center for Medical Biotechnology, VIB
- Francis Impens
- VIB-UGent Center for Medical Biotechnology, VIB
- DOI
- https://doi.org/10.1038/s41467-021-26061-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
During microbial infection, proteins are modified by the ubiquitin-like protein ISG15. Here, the authors uncover RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing that RNF213 has antiviral properties but also directly targets intracellular bacteria in infected cells.
