Nature Communications (Oct 2020)
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
- Xutong Zhao,
- Dandi Qiao,
- Chaojie Yang,
- Silva Kasela,
- Wonji Kim,
- Yanlin Ma,
- Nick Shrine,
- Chiara Batini,
- Tamar Sofer,
- Sarah A. Gagliano Taliun,
- Phuwanat Sakornsakolpat,
- Pallavi P. Balte,
- Dmitry Prokopenko,
- Bing Yu,
- Leslie A. Lange,
- Josée Dupuis,
- Brian E. Cade,
- Jiwon Lee,
- Sina A. Gharib,
- Michelle Daya,
- Cecelia A. Laurie,
- Ingo Ruczinski,
- L. Adrienne Cupples,
- Laura R. Loehr,
- Traci M. Bartz,
- Alanna C. Morrison,
- Bruce M. Psaty,
- Ramachandran S. Vasan,
- James G. Wilson,
- Kent D. Taylor,
- Peter Durda,
- W. Craig Johnson,
- Elaine Cornell,
- Xiuqing Guo,
- Yongmei Liu,
- Russell P. Tracy,
- Kristin G. Ardlie,
- François Aguet,
- David J. VanDenBerg,
- George J. Papanicolaou,
- Jerome I. Rotter,
- Kathleen C. Barnes,
- Deepti Jain,
- Deborah A. Nickerson,
- Donna M. Muzny,
- Ginger A. Metcalf,
- Harshavardhan Doddapaneni,
- Shannon Dugan-Perez,
- Namrata Gupta,
- Stacey Gabriel,
- Stephen S. Rich,
- George T. O’Connor,
- Susan Redline,
- Robert M. Reed,
- Cathy C. Laurie,
- Martha L. Daviglus,
- Liana K. Preudhomme,
- Kristin M. Burkart,
- Robert C. Kaplan,
- Louise V. Wain,
- Martin D. Tobin,
- Stephanie J. London,
- Tuuli Lappalainen,
- Elizabeth C. Oelsner,
- Goncalo R. Abecasis,
- Edwin K. Silverman,
- R. Graham Barr,
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,
- TOPMed Lung Working Group,
- Michael H. Cho,
- Ani Manichaikul
Affiliations
- Xutong Zhao
- Center for Statistical Genetics, and Department of Biostatistics, University of Michigan
- Dandi Qiao
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Chaojie Yang
- Center for Public Health Genomics, University of Virginia
- Silva Kasela
- New York Genome Center
- Wonji Kim
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Yanlin Ma
- Center for Public Health Genomics, University of Virginia
- Nick Shrine
- Genetic Epidemiology Group, Department of Health Sciences, University of Leicester
- Chiara Batini
- Genetic Epidemiology Group, Department of Health Sciences, University of Leicester
- Tamar Sofer
- Department of Medicine, Harvard Medical School
- Sarah A. Gagliano Taliun
- Center for Statistical Genetics, and Department of Biostatistics, University of Michigan
- Phuwanat Sakornsakolpat
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Pallavi P. Balte
- Department of Medicine, Columbia University Medical Center
- Dmitry Prokopenko
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Bing Yu
- Department of Epidemiology, Human Genetics & Environmental Sciences, UTHealth School of Public Health
- Leslie A. Lange
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus
- Josée Dupuis
- Department of Biostatistics, Boston University School of Public Health
- Brian E. Cade
- Department of Medicine, Harvard Medical School
- Jiwon Lee
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Sina A. Gharib
- Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington
- Michelle Daya
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus
- Cecelia A. Laurie
- Department of Biostatistics, University of Washington
- Ingo Ruczinski
- Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
- L. Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Laura R. Loehr
- Department of Medicine, UNC School of Medicine
- Traci M. Bartz
- Department of Biostatistics, University of Washington
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington
- Ramachandran S. Vasan
- Boston University and the National Heart Lung and Blood Institute’s Framingham Heart Study
- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, The Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Peter Durda
- Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont
- W. Craig Johnson
- Department of Biostatistics, University of Washington
- Elaine Cornell
- Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, The Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Yongmei Liu
- Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center
- Russell P. Tracy
- Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont
- Kristin G. Ardlie
- Broad Institute of MIT and Harvard
- François Aguet
- Broad Institute of MIT and Harvard
- David J. VanDenBerg
- Department of Preventive Medicine, University of Southern California
- George J. Papanicolaou
- Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, The Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Kathleen C. Barnes
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado School of Medicine Anschutz Medical Campus
- Deepti Jain
- Department of Biostatistics, University of Washington
- Deborah A. Nickerson
- Department of Genome Sciences, University of Washington
- Donna M. Muzny
- The Human Genome Sequencing Center, Baylor College of Medicine
- Ginger A. Metcalf
- The Human Genome Sequencing Center, Baylor College of Medicine
- Harshavardhan Doddapaneni
- The Human Genome Sequencing Center, Baylor College of Medicine
- Shannon Dugan-Perez
- The Human Genome Sequencing Center, Baylor College of Medicine
- Namrata Gupta
- Broad Institute of MIT and Harvard
- Stacey Gabriel
- Broad Institute of MIT and Harvard
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- George T. O’Connor
- Boston University School Of Medicine, Pulmonary Center
- Susan Redline
- Department of Medicine, Harvard Medical School
- Robert M. Reed
- Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine
- Cathy C. Laurie
- Department of Biostatistics, University of Washington
- Martha L. Daviglus
- Institute for Minority Health Research, University of Illinois at Chicago
- Liana K. Preudhomme
- Department of Psychology, University of Miami
- Kristin M. Burkart
- Department of Medicine, Columbia University Medical Center
- Robert C. Kaplan
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx
- Louise V. Wain
- Genetic Epidemiology Group, Department of Health Sciences, University of Leicester
- Martin D. Tobin
- Genetic Epidemiology Group, Department of Health Sciences, University of Leicester
- Stephanie J. London
- Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services
- Tuuli Lappalainen
- New York Genome Center
- Elizabeth C. Oelsner
- Department of Medicine, Columbia University Medical Center
- Goncalo R. Abecasis
- Center for Statistical Genetics, and Department of Biostatistics, University of Michigan
- Edwin K. Silverman
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- R. Graham Barr
- Department of Medicine, Columbia University Medical Center
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
- TOPMed Lung Working Group
- Michael H. Cho
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Ani Manichaikul
- Center for Public Health Genomics, University of Virginia
- DOI
- https://doi.org/10.1038/s41467-020-18334-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality. Here, the authors analyse whole genome sequence data and find new loci associated with lung function and COPD.
