Reconstruction of ovine axonal cytoarchitecture enables more accurate models of brain biomechanics

Andrea Bernardini; Marco Trovatelli; Michał M. Kłosowski; Matteo Pederzani; Davide Danilo Zani; Stefano Brizzola; Alexandra Porter; Ferdinando Rodriguez y Baena; Daniele Dini

doi:10.1038/s42003-022-04052-x

Communications Biology (Oct 2022)

Reconstruction of ovine axonal cytoarchitecture enables more accurate models of brain biomechanics

Andrea Bernardini,
Marco Trovatelli,
Michał M. Kłosowski,
Matteo Pederzani,
Davide Danilo Zani,
Stefano Brizzola,
Alexandra Porter,
Ferdinando Rodriguez y Baena,
Daniele Dini

Affiliations

Andrea Bernardini: Department of Mechanical Engineering, Imperial College London
Marco Trovatelli: Faculty of Veterinary Medicine, Università degli Studi di Milano Statale
Michał M. Kłosowski: Department of Materials, Imperial College London
Matteo Pederzani: Department of Electronics, Information and Bioengineering, Politecnico di Milano
Davide Danilo Zani: Faculty of Veterinary Medicine, Università degli Studi di Milano Statale
Stefano Brizzola: Faculty of Veterinary Medicine, Università degli Studi di Milano Statale
Alexandra Porter: Department of Materials, Imperial College London
Ferdinando Rodriguez y Baena: Department of Mechanical Engineering, Imperial College London
Daniele Dini: Department of Mechanical Engineering, Imperial College London

DOI: https://doi.org/10.1038/s42003-022-04052-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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Imaging and reconstruction of sheep brain axonal cytoarchitecture provides insight for brain biomechanics models that simulate drug delivery and other biological processes governed by interstitial fluid flow and transport.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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