World Journal of Surgical Oncology (Aug 2007)

Is the thymidine labeling index a good prognostic marker in breast cancer?

  • Igci Abdullah,
  • Muslumanoglu Mahmut,
  • Cabioglu Neslihan,
  • Bilir Ayhan,
  • Ozmen Vahit,
  • Sen-Oran Ebru,
  • Guney Nese,
  • Kecer Mustafa

DOI
https://doi.org/10.1186/1477-7819-5-93
Journal volume & issue
Vol. 5, no. 1
p. 93

Abstract

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Abstract Background The aim of the present study was to determine the prognostic relevance of thymidine labeling index (TLI) in patients with breast cancer. Methods TLI of the primary tumor was measured in 268 patients at the time of the surgical biopsy by an in vitro method. Results Fifty-four patients had stage I disease, and 138 patients had stage II disease, and 76 patients had stage III disease. One hundred-four patients were found to have low TLI-index ( Conclusion Our findings suggest that the prognostic significance of TLI appears to be limited to early breast cancer that might help to distinguish patients who need more aggressive adjuvant treatment.