mBio
(Feb 2021)
Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins
Allison M. Jones,
Petra Virtanen,
Disa Hammarlöf,
William J. Allen,
Ian Collinson,
Christopher S. Hayes,
David A. Low,
Sanna Koskiniemi
Affiliations
Allison M. Jones
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
Petra Virtanen
Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
Disa Hammarlöf
Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
William J. Allen
ORCiD School of Biochemistry, University of Bristol, Bristol, United Kingdom
Ian Collinson
ORCiD School of Biochemistry, University of Bristol, Bristol, United Kingdom
Christopher S. Hayes
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
David A. Low
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
Sanna Koskiniemi
ORCiD Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
DOI
https://doi.org/10.1128/mBio.03367-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Many bacterial species interact via direct cell-to-cell contact using CDI systems, which provide a mechanism to inject toxins that inhibit bacterial growth into one another. Here, we find that two CDI toxins, one that depolarizes membranes and another that degrades RNA, exploit the universally conserved SecY translocon machinery used to export proteins for target cell entry.
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