Leucas aspera mediated SeO nanoparticles synthesis for exploiting its pharmaceutical efficacy

Abstract

abstract: The aim of this study is to synthesis Selenium oxide (SeO) nanoparticles using the leaf extract of Leucas aspera. The leaf extract has been reported to show phytochemicals effective for reducing Selenium precursors. Furthermore, these phytochemicals has being reported to show capping and stabilizing property. As-prepared nanoparticles physico-chemical properties were assessed by a array of various characterization technique. UV-Vis and XRD assessment showed maximum absorbance at 273 nm with high crystalline property. Qualitative assessment using FTIR assessment was performed to assess the phytochemical based functional groups presence which helped in reducing, stabilizing of the prepared nanoparticles. Morphological assessment of nanoparticles showed spherical attributes with good aggregation. Functional attributes of SeO nanoparticles for exploiting its pharmaceutical application, illustrated a significant antibacterial activity against both gram negative and gram-positive strains comparable to commercially available antibiotics. Moreover, MTT assay was employed to assess anticancer behaviour of SeO nanoparticles towards MG-63 cells, which showed effective reduction in cell viability. Furthermore, the study confirms photo catalytic degradation property of SeO nanoparticles towards dye degradation. The study not only discusses the SeO nanoparticles physico-chemical and functional properties, but and also opens future scope of SeO in clinical and environmental applications.

Keywords

• Leucas aspera
• Selenium oxide nanoparticles
• Dye degradation
• Antibacterial activity
• Anti-cancer activity