Nature Communications (Nov 2020)
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow
- Vartika Mishra,
- Diane B. Re,
- Virginia Le Verche,
- Mariano J. Alvarez,
- Alessandro Vasciaveo,
- Arnaud Jacquier,
- Paschalis-Tomas Doulias,
- Todd M. Greco,
- Monica Nizzardo,
- Dimitra Papadimitriou,
- Tetsuya Nagata,
- Paola Rinchetti,
- Eduardo J. Perez-Torres,
- Kristin A. Politi,
- Burcin Ikiz,
- Kevin Clare,
- Manuel E. Than,
- Stefania Corti,
- Harry Ischiropoulos,
- Francesco Lotti,
- Andrea Califano,
- Serge Przedborski
Affiliations
- Vartika Mishra
- Departments of Pathology and Cell Biology, Columbia University
- Diane B. Re
- Center for Motor Neuron Biology and Diseases, Columbia University
- Virginia Le Verche
- Departments of Pathology and Cell Biology, Columbia University
- Mariano J. Alvarez
- Department of Systems Biology, Columbia University
- Alessandro Vasciaveo
- Department of Systems Biology, Columbia University
- Arnaud Jacquier
- Departments of Pathology and Cell Biology, Columbia University
- Paschalis-Tomas Doulias
- Department of Pediatrics, Children’s Hospital of Philadelphia Research Institute and the University of Pennsylvania
- Todd M. Greco
- Department of Pediatrics, Children’s Hospital of Philadelphia Research Institute and the University of Pennsylvania
- Monica Nizzardo
- Departments of Pathology and Cell Biology, Columbia University
- Dimitra Papadimitriou
- Departments of Pathology and Cell Biology, Columbia University
- Tetsuya Nagata
- Departments of Pathology and Cell Biology, Columbia University
- Paola Rinchetti
- Departments of Pathology and Cell Biology, Columbia University
- Eduardo J. Perez-Torres
- Departments of Pathology and Cell Biology, Columbia University
- Kristin A. Politi
- Departments of Pathology and Cell Biology, Columbia University
- Burcin Ikiz
- Departments of Pathology and Cell Biology, Columbia University
- Kevin Clare
- Departments of Pathology and Cell Biology, Columbia University
- Manuel E. Than
- Protein Crystallography Group, Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)
- Stefania Corti
- Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Neurology Unit, IRCCS Foundation Ca’ Granda Ospedale Maggiore Policlinico
- Harry Ischiropoulos
- Department of Pediatrics, Children’s Hospital of Philadelphia Research Institute and the University of Pennsylvania
- Francesco Lotti
- Departments of Pathology and Cell Biology, Columbia University
- Andrea Califano
- Center for Motor Neuron Biology and Diseases, Columbia University
- Serge Przedborski
- Departments of Pathology and Cell Biology, Columbia University
- DOI
- https://doi.org/10.1038/s41467-020-19177-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Neuron-astrocyte communication plays a key role in pathophysiology, however systematic approaches to unveil it are limited. Here, the authors propose SEARCHIN, a multi-modal integrated workflow, as a tool to identify cross-compartment ligand-receptor interactions, applied to ALS models.
