CONTACT ACTIVATION PROTEOLYSIS AND MACROPHAGE INFILTRATION IN TRAUMATIC BRAIN INJURY

Abstract

Matrix metalloproteinases play a significant role in the reorganization of the extracellular matrix and regulation of the blood-brain barrier permeability in traumatic brain injury. In this work it was found that a significant increase in MMP-9 as large as possible on the 7th day was due to marked macrophage infiltration of the blood-CSF barrier. Activation of MMP-9 was also due to its lack of TIMP-1 inhibitor.

Keywords

• traumatic brain injury, macrophageinfiltration, the blood-cerebrospinal fluid barrier, of mmp-9, of timp-1, cd68