Pediatric Hematology Oncology Journal (Dec 2022)
Bizarre parosteal osteochondromatous proliferation in pediatric: A case report and literature review
Abstract
Bizzare parosteal osteochondromatous proliferation (BPOP), first introduced by Nora et al., in 1983, s an uncommon benign bone disease that manifests as a parosteal bone mass that frequently develops in the location of short bones. In our study, we reported an 11-year-old child with BPOP in the second finger of the right hand and the bone lesion was gradually increasing after 14 months of follow-up. Radiographic imaging confirmed an osseous and lobulated mass from the proximal phalanx cortex without the connection with medullary canal of finger. Due to the aggressive nature of the imaging, bone biopsies were performed with ''blue bone'' pathological findings typical of BPOP, with complete resection of the bone exostosis and extended resection of the bone cortex to reduce the recurrence of the lesion. Then, the microarray data of GSE19357 in BPOP was downloaded and analyzed as a result of differentially expressed genes (DEGs), resulting in 11 up-regulated genes including HAPLN1, ACAN, FMOD, DKK3, and P4HA3 with the calculating criteria of P 2. STRING databases were performed to reveal the protein–protein interaction network (PPI) among DEGs. There were 21 nodes and 50 edges with an average local clustering coefficient of 0.624 and PPI enrichment p-value of 3.83e−13. The molecular function in Gene Ontology was highly enriched in Lipoprotein lipase activity, Phospholipase a1 activity, Phosphatidylserine 1-acylhydrolase activity, and Carboxylic acid binding. In Cytoscape, there were three sub-networks of genes with Plugin MCODE, including the relationship of PPARG, FABP4, PRKAR2B, TGFB3 FMOD and DKK3, SULF1, THBS3, HAPLN1 and P4HA3, and LIPG, LPL and PCK1. In this article, we reported a rare case of BPOP in a child with a bone lesion. The DEGs GSE19357 in BPOP were then analyzed and evaluated for the potential molecular mechanism in the diagnosis and treatment of BPOP.
