Pathogens (Apr 2023)

Infection with Seasonal H1N1 Influenza Results in Comparable Disease Kinetics and Host Immune Responses in Ferrets and Golden Syrian Hamsters

  • Jemma Paterson,
  • Kathryn A. Ryan,
  • Daniel Morley,
  • Nicola J. Jones,
  • Paul Yeates,
  • Yper Hall,
  • Catherine J. Whittaker,
  • Francisco J. Salguero,
  • Anthony C. Marriott

DOI
https://doi.org/10.3390/pathogens12050668
Journal volume & issue
Vol. 12, no. 5
p. 668

Abstract

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Animal models of influenza are important in preclinical research for the study of influenza infection and the assessment of vaccines, drugs and therapeutics. Here, we show that Golden Syrian hamsters (Mesocricetus auratus) inoculated via the intranasal route with high dose of influenza H1N1 display comparable disease kinetics and immune responses to the ‘gold standard’ ferret (Mustela furo) model. We demonstrate that both the hamster and ferret models have measurable disease endpoints of weight loss, temperature change, viral shedding from the upper respiratory tract and increased lung pathology. We also characterised both the humoral and cellular immune responses to infection in both models. The comparability of these data supports the Golden Syrian hamster model being useful in preclinical evaluation studies to explore the efficacy of countermeasures against influenza.

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