Frontiers in Immunology (Mar 2023)
An updated review of the immunological mechanisms of keloid scars
- Chih-Chun Lee,
- Chia-Hsuan Tsai,
- Chia-Hsuan Tsai,
- Chih-Hao Chen,
- Chih-Hao Chen,
- Yuan-Chieh Yeh,
- Yuan-Chieh Yeh,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Wen-Hung Chung,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen,
- Chun-Bing Chen
Affiliations
- Chih-Chun Lee
- 1 Department of Medical Education, Chang Gung Memorial Hospital, Keelung, Taiwan
- Chia-Hsuan Tsai
- Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan
- Chia-Hsuan Tsai
- College of Medicine, Chang Gung University, Taoyuan, Taiwan
- Chih-Hao Chen
- Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan
- Chih-Hao Chen
- College of Medicine, Chang Gung University, Taoyuan, Taiwan
- Yuan-Chieh Yeh
- Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan
- Yuan-Chieh Yeh
- Program in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Wen-Hung Chung
- College of Medicine, Chang Gung University, Taoyuan, Taiwan
- Wen-Hung Chung
- Drug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taiwan
- Wen-Hung Chung
- Drug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
- Wen-Hung Chung
- Drug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan
- Wen-Hung Chung
- Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan
- Wen-Hung Chung
- 0Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan
- Wen-Hung Chung
- 1Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China
- Wen-Hung Chung
- 2Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China
- Wen-Hung Chung
- 3Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan
- Wen-Hung Chung
- 4Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan
- Wen-Hung Chung
- 5Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
- Wen-Hung Chung
- 6Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan
- Chun-Bing Chen
- College of Medicine, Chang Gung University, Taoyuan, Taiwan
- Chun-Bing Chen
- Drug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taiwan
- Chun-Bing Chen
- Drug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
- Chun-Bing Chen
- Drug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan
- Chun-Bing Chen
- Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan
- Chun-Bing Chen
- 0Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan
- Chun-Bing Chen
- 1Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China
- Chun-Bing Chen
- 2Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China
- Chun-Bing Chen
- 3Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan
- Chun-Bing Chen
- 4Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan
- Chun-Bing Chen
- 5Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
- Chun-Bing Chen
- 6Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan
- Chun-Bing Chen
- 7School of Medicine, National Tsing Hua University, Hsinchu, Taiwan
- DOI
- https://doi.org/10.3389/fimmu.2023.1117630
- Journal volume & issue
-
Vol. 14
Abstract
Keloid is a type of disfiguring pathological scarring unique to human skin. The disorder is characterized by excessive collagen deposition. Immune cell infiltration is a hallmark of both normal and pathological tissue repair. However, the immunopathological mechanisms of keloid remain unclear. Recent studies have uncovered the pivotal role of both innate and adaptive immunity in modulating the aberrant behavior of keloid fibroblasts. Several novel therapeutics attempting to restore regulation of the immune microenvironment have shown variable efficacy. We review the current understanding of keloid immunopathogenesis and highlight the potential roles of immune pathway-specific therapeutics.
Keywords
