Hepatoid adenocarcinoma of the lung: An analysis of the Surveillance, Epidemiology, and End Results (SEER) database
Lei Lei,
Yang Liu,
Xu Yang-yang,
Chen Hua-fei,
Zhan Ping,
Wang Wen-xian,
Xu Chun-wei
Affiliations
Lei Lei
Department of Chemotherapy, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, No.1 Banshan East Street, Gongshu District, Hangzhou, Zhejiang 310022, People’s Republic of China
Yang Liu
Department of Medical, Shanghai Dunlu Biomedical Technology Co., Ltd., Shanghai 200032, People’s Republic of China
Xu Yang-yang
Department of Medical, Shanghai Dunlu Biomedical Technology Co., Ltd., Shanghai 200032, People’s Republic of China
Chen Hua-fei
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, No. 589 Central West Road, Jiaxing, Zhejiang 314000, People’s Republic of China
Zhan Ping
Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan Road, Jiangsu, Nanjing 210002, People’s Republic of China
Wang Wen-xian
Department of Chemotherapy, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, No.1 Banshan East Street, Gongshu District, Hangzhou, Zhejiang 310022, People’s Republic of China
Xu Chun-wei
Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan Road, Jiangsu, Nanjing 210002, People’s Republic of China
Hepatoid adenocarcinoma of the lung (HAL) is a rare malignant tumor that is defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. We aimed to identify prognostic factors associated with the survival of patients with HAL using data from the Surveillance, Epidemiology, and End Results (SEER) database. We collected data from patients diagnosed with HAL, adenocarcinoma (ADC), and squamous cell carcinoma (SCC) of the lung between 1975 and 2016 from the SEER database. The clinical features of patients with ADC and SCC of the lung were also analyzed. The clinical features of HALs were compared to ADCs and SCCs. A chi-square test was used to calculate the correlations between categorical variables, and a t test or Mann–Whitney U test was used for continuous variables. The Kaplan–Meier method and Cox regression analysis were used to identify the prognostic factors for the overall survival (OS) of HALs. Two-tailed p values 0.05). This study showed that stage IV was the only prognostic factor for OS in HALs compared to other clinicopathologic factors. Conventional antitumor therapies failed to show survival benefit; thus, a more effective method by which to treat HAL is needed. Interestingly, the clinical features and the location of the primary lesion were shown to be associated with primary tumor size and treatment in patients with HAL, which have not been reported before.
