Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

Abstract

The ULK1 complex is required during autophagosome nucleation, but where autophagic membranes initiate is unknown. Here the authors use super-resolution microscopy to propose that autophagosomes originate from tubulovesicular structures in the ER that align with ATG9 vesicles and recruit ULK1.