Feedback regulation of crystal growth by buffering monomer concentration

Samuel W. Schaffter; Dominic Scalise; Terence M. Murphy; Anusha Patel; Rebecca Schulman

doi:10.1038/s41467-020-19882-8

Nature Communications (Nov 2020)

Feedback regulation of crystal growth by buffering monomer concentration

Samuel W. Schaffter,
Dominic Scalise,
Terence M. Murphy,
Anusha Patel,
Rebecca Schulman

Affiliations

Samuel W. Schaffter: Chemical & Biomolecular Engineering, Johns Hopkins University
Dominic Scalise: Chemical & Biomolecular Engineering, Johns Hopkins University
Terence M. Murphy: Our Lady of Lourdes High School
Anusha Patel: Chemical & Biomolecular Engineering, Johns Hopkins University
Rebecca Schulman: Chemical & Biomolecular Engineering, Johns Hopkins University

DOI: https://doi.org/10.1038/s41467-020-19882-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Gaining control over crystallization processes is challenging. Herein, the authors describe a protocol for the controlled growth of DNA nanotubes by feedback regulation: the coupling of a reversible bimolecular monomer buffering reaction delivers the optimal monomer concentration and leads to reliable crystal growth in a simple manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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