Effect of Hydroalcoholic Extract of Berberis Vulgaris Root on Serum Levels of Glucose, Malondehyde and HbA1c in Diabetic Rats

Abstract

Introduction and Aims Diabetes is a common endocrine disorder associated with a variety of diseases such as, stroke, kidney failure and liver cirrhosis. Berberis vulgaris (B. vulgaris) root extract contains various alkaloids that are considered as antioxidants. The aim of this study was to examine serum glucose, glycated hemoglobin (HbA1c) and malondialdehyde (MDA) levels in diabetic rats treated with hydro-alcoholic extract of wild berberis. Materials and Methods In this experimental study, 40 male wistar rats were randomly divided to four groups of healthy control, diabetic control, and two diabetic groups treated with root extract of wild type berberis vulgaris (150 and 300 mg/kg body weight). Type 1 diabetes was induced by a single intraperitoneal injection of streptozocin 42 mg/kg. After 30 days, blood samples were collected from heart and serum glucose, serum MDA, and HbA1c levels were determined by commercial kits. Results Serum glucose, HbA1c, MDA levels were significantly higher in diabetic rats compared to the normal control rats. Oral administration of barberry extract significantly decreased those parameters compared to the untreated diabetic rats. Conclusion Berberis vulgaris root extract has hypoglycemic effect and attenuates lipid peroxidation in diabetic rats * Corresponding Author: University of Zabol, Faculty of Veterinary Medicine. Email: [email protected]

Keywords

• Diabetes Mellitus
• Rats
• Hemoglobin A1c
• Glucose