Nature Communications (Jul 2022)
A SOX17-PDGFB signaling axis regulates aortic root development
- Pengfei Lu,
- Ping Wang,
- Bingruo Wu,
- Yidong Wang,
- Yang Liu,
- Wei Cheng,
- Xuhui Feng,
- Xinchun Yuan,
- Miriam M. Atteya,
- Haleigh Ferro,
- Yukiko Sugi,
- Grant Rydquist,
- Mahdi Esmaily,
- Jonathan T. Butcher,
- Ching-Pin Chang,
- Jack Lenz,
- Deyou Zheng,
- Bin Zhou
Affiliations
- Pengfei Lu
- Department of Genetics, Albert Einstein College of Medicine
- Ping Wang
- Department of Genetics, Albert Einstein College of Medicine
- Bingruo Wu
- Department of Genetics, Albert Einstein College of Medicine
- Yidong Wang
- Department of Genetics, Albert Einstein College of Medicine
- Yang Liu
- Department of Genetics, Albert Einstein College of Medicine
- Wei Cheng
- Department of Genetics, Albert Einstein College of Medicine
- Xuhui Feng
- Department of Genetics, Albert Einstein College of Medicine
- Xinchun Yuan
- Department of Genetics, Albert Einstein College of Medicine
- Miriam M. Atteya
- Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina
- Haleigh Ferro
- Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina
- Yukiko Sugi
- Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina
- Grant Rydquist
- School of Mechanical and Aerospace Engineering, Cornell University
- Mahdi Esmaily
- School of Mechanical and Aerospace Engineering, Cornell University
- Jonathan T. Butcher
- School of Biomedical Engineering, Cornell University
- Ching-Pin Chang
- Department of Genetics, Albert Einstein College of Medicine
- Jack Lenz
- Department of Genetics, Albert Einstein College of Medicine
- Deyou Zheng
- Department of Genetics, Albert Einstein College of Medicine
- Bin Zhou
- Department of Genetics, Albert Einstein College of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31815-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Little is known about the developmental causes of aortic root defects. Here the authors show that the inactivation of Sox17 in aortic root endothelium results in aortic root defects affecting aortic valve and coronary ostium.
