The features of lipid and carbohydrate metabolism in the indigenous population of the north of Yakutia are studied depending on ethnicity. The analysis of blood parameters found that the average values of atherogenic low-density lipoprotein cholesterol exceeded reference values in all ethnic groups. The high frequency of hypercholesterolemia due to the atherogenic fraction in all ethnic groups was shown, the highest was observed in Evenks and Yakuts. The frequency of hyperglycemia is significantly higher in the Dolgans, Evenks and Yakuts in comparison with other ethnic groups.