Frontiers in Pharmacology (Apr 2023)
Emerging role of ferroptosis-related circular RNA in tumor metastasis
- Yifei Meng,
- Yifei Meng,
- Yifei Meng,
- Yifei Meng,
- Yifei Meng,
- Jingdong Cao,
- Jingdong Cao,
- Jingdong Cao,
- Jingdong Cao,
- Jingdong Cao,
- Yidan Li,
- Yidan Li,
- Yidan Li,
- Yidan Li,
- Yidan Li,
- Saili Duan,
- Saili Duan,
- Saili Duan,
- Saili Duan,
- Saili Duan,
- Zongjiang Zhou,
- Zongjiang Zhou,
- Jinghe Li,
- Jinghe Li,
- Diabate Ousmane,
- Diabate Ousmane,
- Chunlin Ou,
- Chunlin Ou,
- Junpu Wang,
- Junpu Wang,
- Junpu Wang,
- Junpu Wang,
- Junpu Wang
Affiliations
- Yifei Meng
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Yifei Meng
- Department of Pathology, School of Basic Medicine, Central South University, Changsha, China
- Yifei Meng
- Department of Pathology, Ultrapathology (Biomedical Electron Microscopy) Center, Xiangya Hospital, Central South University, Changsha City, China
- Yifei Meng
- Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yifei Meng
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Jingdong Cao
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Jingdong Cao
- Department of Pathology, School of Basic Medicine, Central South University, Changsha, China
- Jingdong Cao
- Department of Pathology, Ultrapathology (Biomedical Electron Microscopy) Center, Xiangya Hospital, Central South University, Changsha City, China
- Jingdong Cao
- Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China
- Jingdong Cao
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yidan Li
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Yidan Li
- Department of Pathology, School of Basic Medicine, Central South University, Changsha, China
- Yidan Li
- Department of Pathology, Ultrapathology (Biomedical Electron Microscopy) Center, Xiangya Hospital, Central South University, Changsha City, China
- Yidan Li
- Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yidan Li
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Saili Duan
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Saili Duan
- Department of Pathology, School of Basic Medicine, Central South University, Changsha, China
- Saili Duan
- Department of Pathology, Ultrapathology (Biomedical Electron Microscopy) Center, Xiangya Hospital, Central South University, Changsha City, China
- Saili Duan
- Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China
- Saili Duan
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Zongjiang Zhou
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Zongjiang Zhou
- Department of Pathology, School of Basic Medicine, Central South University, Changsha, China
- Jinghe Li
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Jinghe Li
- Department of Pathology, School of Basic Medicine, Central South University, Changsha, China
- Diabate Ousmane
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Diabate Ousmane
- Department of Pathology, School of Basic Medicine, Central South University, Changsha, China
- Chunlin Ou
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Chunlin Ou
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Junpu Wang
- Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
- Junpu Wang
- Department of Pathology, School of Basic Medicine, Central South University, Changsha, China
- Junpu Wang
- Department of Pathology, Ultrapathology (Biomedical Electron Microscopy) Center, Xiangya Hospital, Central South University, Changsha City, China
- Junpu Wang
- Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China
- Junpu Wang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fphar.2023.1168458
- Journal volume & issue
-
Vol. 14
Abstract
Tumor metastasis is an important factor that contributes to the poor prognosis of patients with tumors. Therefore, to solve this problem, research on the mechanism of metastasis is essential. Ferroptosis, a new mode of cell death, is characterized by membrane damage due to lipid peroxidation caused by iron overload. Many studies have shown that excessive ferroptosis can affect tumor metastasis and thus inhibit tumor progression. Recently, circular RNA (circRNA), a type of non-coding RNA, has been shown to be associated with the progression of ferroptosis, thus influencing tumor development. However, the specific mechanisms by which circRNAs affect the progression of ferroptosis and their roles in tumor metastasis are not known. In this review, we systematically discuss the role of circRNAs in regulating tumor ferroptosis and their mechanism of action through sponging miRNAS in various tumors, thereby impacting metastasis. This review helps elucidate the relationship and role of ferroptosis-related circRNAs in tumor metastasis and may provide future researchers with new ideas and directions for targeted therapies.
Keywords
