Crystal structure and Hirshfeld surface analysis of the hydrochloride salt of 8-{4-[(6-phenylpyridin-3-yl)methyl]piperazin-1-yl}-3,4-dihydroquinolin-2(1H)-one

Abstract

The amine 8-{4-[(6-phenylpyridin-3-yl)methyl]piperazin-1-yl}-3,4-dihydroquinolin-2(1H)-one was crystallized as the hydrochloride salt, 4-(2-oxo-1,2,3,4-tetrahydroquinolin-8-yl)-1-[(6-phenylpyridin-3-yl)methyl]piperazin-1-ium chloride, C25H27N4+·Cl− (I·HCl). The conformation of the organic cation is half-moon in shape enclosing the chloride anion. The piperidine ring of the 3,4-dihydroquinolin-2(1H)-one moiety has a screw-boat conformation, while the piperazine ring has a chair conformation. In the biaryl group, the pyridine ring is inclined to the phenyl ring by 40.17 (7) and by 36.86 (8)° to the aromatic ring of the quinoline moiety. In the crystal, the cations are linked by pairwise N—H...O hydrogen bonds, forming inversion dimers enclosing an R22(8) ring motif. The Cl− anion is linked to the cation by an N—H...Cl hydrogen bond. These units are linked by a series of C—H...O, C—H...N and C—H...Cl hydrogen bonds, forming layers lying parallel to the ab plane.

Keywords

• crystal structure
• dihydroquinolin-2(1h)-one
• piperazine
• hydrochloride
• molecular salt
• dopamine d2 receptor
• serotonin 5-ht1a receptor
• hydrogen bonding
• hirshfeld surface analysis