Nature Communications (Sep 2021)
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge
- Weixian Xi,
- Vishal Hegde,
- Stephen D. Zoller,
- Howard Y. Park,
- Christopher M. Hart,
- Takeru Kondo,
- Christopher D. Hamad,
- Yan Hu,
- Amanda H. Loftin,
- Daniel O. Johansen,
- Zachary Burke,
- Samuel Clarkson,
- Chad Ishmael,
- Kellyn Hori,
- Zeinab Mamouei,
- Hiroko Okawa,
- Ichiro Nishimura,
- Nicholas M. Bernthal,
- Tatiana Segura
Affiliations
- Weixian Xi
- Department of Chemical and Biomolecular Engineering, University of California Los Angeles
- Vishal Hegde
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Stephen D. Zoller
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Howard Y. Park
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Christopher M. Hart
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Takeru Kondo
- Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of Dentistry
- Christopher D. Hamad
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Yan Hu
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Amanda H. Loftin
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Daniel O. Johansen
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Zachary Burke
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Samuel Clarkson
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Chad Ishmael
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Kellyn Hori
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Zeinab Mamouei
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Hiroko Okawa
- Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of Dentistry
- Ichiro Nishimura
- Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, University of California Los Angeles School of Dentistry
- Nicholas M. Bernthal
- Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles
- Tatiana Segura
- Department of Chemical and Biomolecular Engineering, University of California Los Angeles
- DOI
- https://doi.org/10.1038/s41467-021-25383-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Implant infection is the most common mode of joint replacement failure with serious complications. Here, the authors report on the in vivo application of a prophylactic coating technology that can incorporate a range of antibiotics and be applied in the operating room prior to implantation.
