Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons

Abstract

In neurons, brain-derived neurotrophic factor (BDNF) transcription is activated by synaptic activity, in part by epigenetic regulation of its promoter regions. Here the authors characterize histone modifications in response to NMDA treatment that result in different kinetics of Bdnf activation from its different promoter regions.