Methane (CH4) emissions are a leading cause of global warming, and precise monitoring of and reduction in these emissions are important. To achieve these goals, miniaturized low-power sensor systems with improved precision are necessary. To this end, we present a novel room-temperature chemiresistive CH4 gas sensor that employs Zn-hexahydroxytriphenylene-based metal–organic frameworks (Zn-HHTP MOFs) as detection materials. The high surface area and porosity of Zn-HHTP MOFs enable effective detection of low atmospheric levels (1.2 ppm) of CH4.