Nature Communications (Nov 2019)

Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish

  • Caroline Coombs,
  • Antonios Georgantzoglou,
  • Hazel A. Walker,
  • Julian Patt,
  • Nicole Merten,
  • Hugo Poplimont,
  • Elisabeth M. Busch-Nentwich,
  • Sarah Williams,
  • Christina Kotsi,
  • Evi Kostenis,
  • Milka Sarris

DOI
https://doi.org/10.1038/s41467-019-13107-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Inflammatory responses must be induced and resolved timely to serve protection from pathogens without inducing excessive tissue damage. Here the authors use live imaging in zebrafish to show that the intracellular trafficking of two chemokine receptors, Cxcr1 and Cxcr2, is differentially regulated on activated neutrophils to control their clustering and dispersal, respectively.